http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004041213-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1402d6f5ce534d1715c3c55dbd82058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_346589dd02ec681368cabb892ba56c37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1779c4ab7133b0c4994a0604bc4d8b22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fdbcd91afe222be9465f712aaa12d7ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6dc116ab0c810d38f16d6c895096ad6b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2821 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-567 |
| filingDate | 2003-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f67fd0ec69187e0577212f1f1c68370a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7207a077f5572a0f270576392d96e52c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc466e3297bde311085d3231c865a3e2 |
| publicationDate | 2004-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2004041213-A3 |
| titleOfInvention | Methods for the identification of agents that modulate the structure and processing of beta-amyloid precursor protein |
| abstract | The present invention provides methods for the screening and identification of agents from a large library of molecular structures that can alter the cleavage of amyloid precursor protein (AP). Agents identified by the methods of the present invention that modify the cleavage of APP can be used in the treatment and prevention of Alzheimer's disease. The methods select for and identify effector agents that bind to APP causing a structural change in the structure of APP in such a way that the efficiency of the cleavage of a secretase is modulated. Further, the methods are carried out in an in vivo system that provides for physiological conditions similar or identical to conditions for APP processing. Agents can be selected for their ability to cause a decrease in the amount of ß-secretase or ?-secretase cleavage of APP, or for an increase in a-secretase cleavage of APP. The agents can be, particularly peptide agents, can be converted into a peptidominetic, an isosteric replacement compound, a D-amino acid analog, or non-peptidyl compound for treating Alzheimer's disease or any other amyloid related or prion related disease. The agents or derivatives thereof can be formulated for intravenous, parenteral, topical, sustained release, intranasal, or inhalation use. |
| priorityDate | 2002-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.