| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f82553fe48672af901d67af93603499e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47575320eb7085380444b3ada4bb6cba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45a3703d03a4b21be619937f5ad63b8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0a5da74eacd4a1d13f593b7c9f1009d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78941ed5a01bfbcd48376e1fdb485b19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_142204a88c5dd416a910c79ef38eb4b9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70 |
| filingDate |
2003-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a75c3c3ee61d51009a2398a46e3aa50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2663e2e2cd5dfb9a02d8dc9b8f013894
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5ec1bea8fe242d6e8764e487ec1bcb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1750ab3b5b231fcbcd7ebac686f2365 |
| publicationDate |
2004-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004037852-A2 |
| titleOfInvention |
Thymidylate synthase polymorphisms for use in screening for cancer susceptibility |
| abstract |
The present invention discloses a novel single nucleotide polymorphism (SNP) in the isolated 5' tandem repeats of the thymidylate synthase (TS) gene and methods for its use. The novel SNP, located in the 12th nucleotide of a 28 bp third tandem repeat (3R) of the TS gene, substitutes a C for a G, and is the variant form of the repeat. Subjects with the wild-type form of 3R have greater transcription of the TS gene than subjects with the variant form. The invention also reveals that a six base pair deletion in the 3' region of TS (-6 bp/1494) indicates mRNA instability and thus reduced production of TS. In diseased tissue, such as cancer, reduced production of TS is beneficial because it prevents the cancerous cells from growing and spreading. Analysis of either polymorphism or both together allows for prediction of a subject's response to chemotherapeutic and anti-cardiovascular disease treatments because both diseases are related to TS levels in a subject. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2006070666-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1540012-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006070666-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7662553-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011160216-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015132569-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774385-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1540012-A2 |
| priorityDate |
2002-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |