| abstract |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as nuclear hormone receptor modulators. The compounds of the instant invention are ligands for nuclear hormone receptors and as such may be useful for treatment or prevention of a variety of conditions related to nuclear hormone functioning including proliferative diseases, cancers, benign prostate hyperplasia, adenomas and neoplasisms of the prostate, benign or malignant tumor cells containing the androgen receptor, cardiovascular diseases, angiogenic conditions or disorders, hirsutism, acne, hyperpilosity, inflammation, immune modulation, seborrhea, endometriosis, polycycstic ovary syndrome, androgen alopecia, hypogonadism, osteoporosis, suppressing spermatogenesis, libido, cachexia, anorexia, cancers expressing the estrogen receptor, prostate cancer, breast cancer, endometrial cancer, incontinence, hot flashes, vaginal dryness, menopause, contraception, pregnancy termination, cancers containing the progesterone e receptor, endometriosis, cachexia, menopause fibrosis, labor induction, autoimmune diseases, impairment of cognitive functioning, cerebral degenerative disorders, Alzheimer's disease, psychotic disorders, type-II diabetes, congestive heart failure, disregulation of cholesterol or lipid homeostasis, and/or obesity. A compound having the general formula I or II: |