Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_676b80da7ac92b84e447a83fb1630ae1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_699d3f0b3e9bcdfaaed8196ff446e0a0 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
filingDate |
2003-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8ff2ab65dd1f98cec04b40f057a2880 |
publicationDate |
2004-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2004028464-A2 |
titleOfInvention |
Methods and compositions for modification of splicing of pre-mrna |
abstract |
The present invention provides a method of preventing a splicing event in a pre-mRNA molecule, comprising contacting the pre-mRNA and/or elements of the splicing machinery with a small molecule compound identified according to the methods described herein to prevent the splicing event in the pre-mRNA molecule. Further provided is a method of inducing a splicing event in a pre-mRNA molecule, comprising contacting the pre-mRNA and/or elements of the splicing machinery with a small molecule compound identified according to the methods described herein to induce the splicing event in the pre-mRNA molecule. Furthermore, a method is provided herein of treating a patient having a disorder associated with an alternative or aberrant splicing event in a pre-mRNA molecule, comprising administering to the patient a therapeutically effective amount of a compound identified according to the methods described herein to prevent an alternative or aberrant splicing event in a pre-mRNA molecule, thereby treating the patient. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11371077-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8193168-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1874791-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008539698-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3020829-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3020829-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879014-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009027077-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009027077-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1874791-A4 |
priorityDate |
2002-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |