| abstract |
The invention provides methods and reagents for detecting cell proliferation and for modulating cell death and cell proliferation by modulating polo-like kinases. More specifically, the invention identifies Serine-4 as a novel phosphorylation site on the B23 polypeptide, and identifies Plk's as being responsible for phosphorylating B23 at this site. This phosphorylation, in part, leads to chromosome decondensation, which is a pre-requisite for mitotic division. |