| abstract |
The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands. Forumla (I) or a salt thereof, wherein A is heterocycle selected from pyrrolidinyl or piperidinyl, wherein he heterocycle is substituted with 0, 1, 2, 3 or 4 substituents selected from the group consisting of alkyl and fluoroalkyl; and R 1 is 4-cyanophenyl, aryl, or heteroaryl, wherein he phenyl of 4-cyanophenyl, the aryl, or the heteroaryl is substituted with 0, 1, 2, 3 or 4 substituents seleced from the group consisting of alkoxy, alkoxyalkyl, alkyl, alkylthio, alkylthioalkyl, cyano, haloalkoxy, halogen, and haloalkyl. |