| abstract |
It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1): (1) In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(=O) or NR11; and D is a group represented by the following general formula (4) or (6). or (4) -Q-Y-B (6) In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). -(CR18R19)m3- or -(CR20R21)m4-z-(CR22R23)m5- (7) z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents -NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl. |