abstract |
Plag 1 and Plag L2, two members of the Plag gene family, have oncogenic capacity and expression of Plag1 is highly upregulated in pleomorphic salivary gland adenomas. The present invention discloses Plag transgenic mouse strains and Plag knockout mice and reveals that the Plag proteins are crucial targets to diagnose and/or treat urine/faeces retention, several neoplasms, infertility, heart failure and/or aberrant body weight. |