http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004018697-A2

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filingDate 2003-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c09dcbe8a3a18f44d02284bdf09a925
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publicationDate 2004-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2004018697-A2
titleOfInvention Protease resistant ti-growth hormone releasing hormone
abstract One aspect of the current invention is a composition for a modified growth hormone releasing hormone ('GHRH') or functional biological equivalent thereof. Another aspect of the current invention includes a nucleic acid molecule that encodes the modified GHRH or functional biological equivalent. The modified GHRH can be defined as a biologically active polypeptide that was engineered to contain a distinct amino acid sequence while simultaneously having similar or improved biologically activity when compared to a wild-type GHRH ('wt-GHRH') polypeptide. Another aspect of the current invention includes a method for delivering the composition of this invention to a subject, wherein the modified GHRH increases the level of growth hormone ('GH') secretion in a subject. The preferred subject is a human or domesticated animal. Additionally, the modified GHRH composition is resistant to degradation when compared to the wt-GHRH.
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