http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004018501-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e3728dd395b6cc22663f970a0e034e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_981bd40e09e54c15fdfc1a38501a341e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51831cdc95a5ce0e64871dd2d01987c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c841ace0c9fe30884d4a58aff4d0639 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7da3ff327f139608f183db04a550a68b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a25fbf3e36c92a6fb2bd2e82ff2c9b33 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 |
| filingDate | 2002-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ede5f85c5958c5368ec9ae98e386060 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2343e50ce3c4c46afee121626e400d66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b1c34ab8bc8b7643d6728abf349421b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94af3d1efc99c0412409b87ceebb4a2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40d5aa6698d9e2b1ffe823649e19cd82 |
| publicationDate | 2004-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2004018501-A1 |
| titleOfInvention | Method for synthesizing peptides |
| abstract | The present invention relates to a novel method for synthesizing peptides in solution, the method comprising: a) treating a peptide or amino acid derivative, which has an α-amine function blocked with a urethane group of the formula R1-SO2-CH2CH2-O-CO-, wherein R1 is aryl, with an excess of an aliphatic secondary amine in an organic solvent to provide the release of the free α-amine function of said amino acid or peptide derivative and the formation of a tertiary amine adduct between said secondary amine and the liberated vinyl compound of the formula R1-SO2-CH2=CH2; b) removing the solvent and the excess of said secondary amine; c) contacting thus formed mixture of the Nα-deprotected amino acid or peptide derivative and said tertiary amine adduct with subsequent peptide or amino acid derivative Nα-protected with the above indicated or another urethane group under conditions providing the formation of a peptide bond between the free α-amine function of the Nα-deprotected amino acid or peptide derivative and an α-carboxylic function of the subsequent Nα-protected peptide or amino acid derivative; d) separating the newly formed peptide from the reaction mixture; e) repeating procedures as set forth above until the desired polypeptide is obtained. |
| priorityDate | 2002-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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