| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbe441ddc24427b876a39b6464f17348
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6626348c1c71caedb8f4b9d2829ef4cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3e077d0a59db8ff61f9a274be1ee492
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8fd73c93f29359c2391f306b93dc8732 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0659
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate |
2003-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_235d9d8c5f442bb7454b71e4747d4189
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5671649f9c6b3fde07f55ac98a489f57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14d68df1a24d2775d340d3f6adb76fd5 |
| publicationDate |
2004-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004012503-A2 |
| titleOfInvention |
Compositions comprising muscle progenitor cells and uses thereof |
| abstract |
The present invention shows the in vivo myogenic differentiation of muscle progenitor cells (MPCs), being derived from joint tissue, in a mouse model of skeletal muscle regeneration. MPCs participated in the regeneration process by long-term persistence and contribution to the compartment of myonuclei and the pool of functional satellite cells. When injected into dystrophic muscles of immunosuppressed mdx mice, human MPCs restored dystrophin in some fibers, and rescued the expression of mouse mechano-growth factor. In addition, the human MPCs derived from synovial membrane were injected into infarcted myocardial muscle. The MPCs engrafted successfully, underwent proliferation and differentiation leading to functional recovery and maintenance of the cardiac muscle. MPCs represent an alternative source of myogenic cells in therapeutic approaches for postnatal skeletal and cardiac muscle repair. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2209482-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9499791-B2 |
| priorityDate |
2002-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |