| abstract |
The present invention relates to solid dispersion comprising amlodipine which enables formulations adequate for oral administration through raising the solubility and dissolution rate of amlodipine with low water solubility, one of the therapeutics for hypertension, and manufacturing method thereof and a pharmaceutical composition comprising the solid dispersion. The present invention can provide pharmaceutical composition comprising solid dispersion of amlodipine which, compared to the conventional amlodipine besylate, exhibits a unique combination of properties important for the preparation of pharmaceutical composition, i.e. superior stability, nonhygroscopicity and superior processibility, in particular, excellent sticking-preventing property. |