| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8070fc6125ae579fa9d6c5a945ab6e58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c029663bd119d6b4e46e01874a0b6cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c1f3a675448fe6e0b2adbbe72a0857b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ac9a9baaf1b2396ac26b36d2f8c3a12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1dc41849652d594c6eeb97385fe9fe2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ffb31806999b284f66e6311ed95ffc6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 |
| filingDate |
2003-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d0067308a5f89a1411856256633e686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_769276a34ca624db72624ab419f0b48d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43d5f57b1e75bef268ea75de8670acfc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_933a5f7a3a2b7675716391274cd2b1d0 |
| publicationDate |
2004-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004009629-A1 |
| titleOfInvention |
Monomeric insulin |
| abstract |
This invention provides a novel monomeric insulin (B27K-DTrI, B27K-destripeptide-Insulin), its composition and the method of preparation therefore. Highly pure B27K-DTrI-Insulin is monomeric (non-associative at high concentration and physiological pH) with in-vivo bioactivity being 80% of that of native insulin. B27K-DTrI-Insulin can be produced by enzyme cleavage of a monomeric insulin precursor secreted by yeast instead of by the less efficient enzyme transpeptidation as known in the prior art. The new method increases the total yield and is favorable for industrial production. |
| priorityDate |
2002-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |