| abstract |
The invention concerns a compound of general formula (I), wherein: R1 represents an optionally substituted C1-6 alkyl, a C3-7 cycloalkyl, a thiophene, a benzothiophene, a pyridinyl, a furanyl or a phenyl; the phenyl groups being optionally substituted; R2 and R'2 represent independently of each other a hydrogen atom, a halogen atom, a hydroxy, a C1-3 alkoxy, a C1-3 alkyl, a C3-7 cycloalkyl, a O-C(O)-C1-6 alkyl group, or R2 and R'2 together form an oxo group; R3 represents a hydrogen atom, a C1-16 alkyl optionally substituted by a hydroxy or a C1-3 alkoxy; R4 and R5 represent, independently of each other a hydrogen atom, an optionally substituted C1-7 alkyl, a C3-7 cycloalkyl, a phenyl, a naphthyl or a -C(X)R6; the C3-7 cycloalkyl and phenyl groups being optionally substituted; provided that at least one R4 or R5 group represents a -C(X)R6 group; X represents an oxygen atom or a sulphur atom; R6 represents a C1-6 alkoxy group, a hydroxy or a -NR7R8 group; the C1-6 alkoxy group being optionally substituted by a phenyl; R7 and R8 represent, independently of each other a hydrogen atom, an optionally substituted C1-6 alkyl group, a C3-7 cycloalkyl, C1-6 alkoxy or a phenyl; or R7 and R8, together with the atom bearing them form an aziridine, azetidine, pyrrolidine, piperidine or morpholine cycle; the C3-7 cycloalkyle and phenyl groups being optionally substituted; in the form of base, addition salt to an acid or hydrate. The invention is applicable in therapeutics. |