| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3608a58ac2d338e9bd664ac2f722d31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_280d87031f0c5786de1808713a1b76b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b6931b7c3bde4280f1c66997d27b42f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2003-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b7c1818989ad5f7e138780c21ca7e53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93702681b47e03f1d3af02704cdf581e |
| publicationDate |
2004-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004009127-A1 |
| titleOfInvention |
Localized delivery system for phenstatin using n-isopropylacrylamide |
| abstract |
An injectable drug delivery system for localized release of Phenstatin to a tumor site over a period of time is provided. The drug delivery system comprises the thermoresponsive polymer N-isopropylacrylamide (NIPAAm) and Phenstatin, a toxic antineoplastic agent. The drug delivery system has a critical solution temperature (LCST) that causes it to change from the liquid state at room temperature when injected to a gel or semi-solid state after reaching the temperature of the human body in situ. Methods are given for delivering Phenstatin to a cancerous tumor. In these methods, the drug delivery system is injected into a tissue or into a tumor where it forms a gel. Phenstatin is slowly released from the polymer and exerts its cytotoxic, tublin-related effects on the tumor. Tumors that may be treated by the present methods include, but are not limited to breast, prostate, lung and bowel cancerous tumors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004046258-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004046258-A2 |
| priorityDate |
2002-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |