| abstract |
The invention relates to a method for producing 17ss-substituted 4-aza-androst-1-ene-3-one compounds of the general formula (I), or a pharmaceutically approved salt thereof by (A) introducing protective groups into the 3-keto-4-aza group of the corresponding 1,2-dihydro compound, thereby producing a compound of the general formula (III), (B) reacting the compound so obtained in the presence (i) of a dehydration catalyst, and in the presence of (ii) optionally substituted benzoquinone, allylethylcarbonate and/or allylpropylcarbonate, and, (C) removing the protective groups R3 and R4 and optionally converting the compound so obtained to a salt. |