| abstract |
A recombinant poxvirus, wherein the poxvirus genome does not comprise a functional gene encoding a 3β-hydroxysteroid dehydrogenase/Δ5-Δ4isomerase, may be used for vaccination against infection by a poxvirus. The recombinant poxvirus in which, additionally, the poxvirus genome comprises a non-poxvirus gene or a fragment of a non-poxvirus gene which gene or fragment encodes an antigen, for example, of a pathogenic agent, may be used to induce an immune e response against the antigen, for example, for vaccination against infection by the pathogenic agent. |