| abstract |
This invention relates to new derivatives of rifabutine of general formula I, wherein R1 is hydrogen or COR2 in which R2 is independently selected from saturated or insaturated linear, branched or cyclic alkyl C1-C20; R3 is oxygen or hydroxyl; R4 is a nitrogen atom or N-oxide, and their acceptable salts and solvates, including hydrates. These derivatives are useful as anti-infectious agents, namely against Mycobacterium avium, and Mycobacterium tuberculosis. (I) |