| abstract |
A method of treating or preventing a disorder related to excessive formation of vascular tissue or blood vessels, including neovascular glaucoma, retinopathy, nephropathy, a cardiovascular disease or a cancerous disease. Said method comprises administering to a patient an agent affecting the neuropeptide Y (NPY) Y2 receptor. Said agent may be an NPY Y2 receptor antagonist, such as an antisense oligonucleotide complementary to any part of the Y2 receptor mRNA, an antibody against the Y2 receptor, an aptamer, a small interfering RNA molecule (siRNA), a ribozyme or a dipeptidyl peptidase IV inhibitor. |