| abstract |
All multiple myeloma cell lines examined showed constitutively active IkB kinase (IKK), IkBα phosphorylation and constitutively active NF-kB. Curcumin, a chemopreventive agent, suppressed constitutive IkBα phosphorylation through inhibition of IKK activity and downregulated NF-kB. Curcumin also downregulated expression of NF-kB-regulated gene products such as IkBα, Bcl-2, Bcl-xL, cyclin D1 and interleukin-6. Consequently, curcumin suppressed multiple myelona cell proliferation and arrested cells at the G1/S phase of the cell cycle. Curcumin also induced apoptosis and chemosensitivity to vincristine. Overall, results presented herein provide a molecular basis for the treatment of multiple myelona patients with this pharmacologically safe agent. |