| abstract |
The present invention is concerned with fluorobenzamide derivatives of the generalnformula Wherein R 1 is hydrogen, (C 1 -C 6 )-alkyl ornhydroxy-( C1 -C 6 )-alkyl; R 2 is (C 1 -C 6 )-alkyl, -CO-NR 8 R 9 ,n-(CH 2 ) n -NR 8 R 9 , -(CH 2 ) P -OR 8 ,nor -(CH 2 ) n -CN; R 3 is selected from hydrogen,nhalogen, halogen-(C 1 -C 6 )-alkyl, cyano, C 1 n-C 6 -alkoxy or halogen-(C 1 -C 6 )-alkoxy; R 4 ,nR 5 , R 6 and R 7 are hydrogen or fluoro, and at leastnone of R 4 , R 5 , R 6 and R 7 is fluoro; R 8 nand R 9 independently from each other are hydrogen or (C 1 -C 6 )-alkyl;nm is 1, 2 or 3; n is 0, 1, 2 or 3; and p is 1 or 2; as well as their pharmaceutically acceptablensalts. The compounds of general formula I are selective monoamine oxidase B inhibitorsnand therefore they are suitable for the treatment of Alzheimer's diseasenor senile dementia. |