http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03105676-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d5559b36e21473806012cfe55f43294 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e449a3fcfdc6648abcfe37fd6586eb9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-363 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4826 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-486 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 |
| filingDate | 2003-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6030f44033b790bbbb61b10df44246da |
| publicationDate | 2003-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03105676-A2 |
| titleOfInvention | Compositions and methods for reducing lung volume |
| abstract | The invention includes methods for performing non-surgical lung volume reduction in a patient by (a) administering, through the patient's trachea, a composition comprising an enzyme (e.g., a protease, such as a serine protease (e.g., trypsin, chymotrypsin, elastase, or an MMP); and (b) collapsing a region of the lung, at least a portion of which was contacted by the composition administered in step (a). The patient can have COPD (e.g., emphysema) or their lung can be damaged by a traumatic event. The tissue in the targeted area can also include an abscess or fistula. One can similarly treat other tissues (i.e., non-lung tissues) by exposing those tissues to an enzyme-containing composition (or other composition described herein). These tissues may be those that are obscured from a therapeutic agent by epithelial cells or that will contact an implantable device. Where the lung is targeted, one can collapse a region of the lung by administering, to the targeted region, a substance that increases the surface tension of fluids lining the alveoli in the targeted region, the surface tension being increased to the point where the region of the lung collapses. The concentration of the active agents in the compositions of the invention are described further below, but we note here that the concentrations will be sufficient to damage the epithelial cell lining of the lung or the epithelium lining or otherwise covering another tissue. The compositions described herein can be used not only for lung volume reduction and other tissue treatments, but also for use as medicaments, or for use in the preparation of medicaments, for treating patients who have a disease or condition that would benefit from selective epithelial damage and subsequent fibrosis or scar formation (e.g., a disease or condition in which the target cells would otherwise be obscured by the epithelial lining of a tissue or one that can be treated with an implanted device (e.g., a valve, pump, or prosthetic device). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006066234-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7654998-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113425965-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7300428-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006066234-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007055950-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007055950-A2 |
| priorityDate | 2002-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 499.