| abstract |
Provided herein are type II transmembrane serine protease 12 (MTSP12) polypeptides. Zymogen and activated forms of these polypeptides, including single and two chain forms of each protease domain and multi-chain forms containing a plurality of protease domains also are provided. Multi-chain forms of the MTSP12 containing two, three, four or more chains are provided as are molecules containing one, two or three of the protease domains, in any order, and as single or multiple chains are provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP12 are provided. |