| abstract |
Drugs having an inhibitory activity against IKK-β and/or MEKK-1 or other proteinnkinases similar thereto in structure, which contain as the active ingredient substancesnselected from the group consisting of compounds represented by the general formulan(I), pharmacologically acceptable salts thereof, and hydrates and solvatesnof both: (I) wherein X is a connecting group whose main chain has 2 to 5 atoms andnwhich may have a substituent; A is hydrogen or acetyl; E is optionally substitutednaryl or optionally substituted heteroaryl; and Z is arene which may have a substituentnin addition to the groups represented by the general formulae: -O-A (whereinnA is as defined above) and -X-E (wherein X and E are as defined above) or heteroarenenwhich may have a substituent in addition to the groups represented by the generalnformulae: -O-A (wherein A is as defined above) and -X-E (wherein X and E are as definednabove). |