http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03095640-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_529aa05fd1303f58f7cc6cbf320e8906 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aaf7a33045683372c407f3c4190c701c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d466be25a7bcade71087d1364c441de7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0318 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2003-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_497496d693517c856da53885bb0d991a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_219a28eeda4ae2664cf697cf62ff0271 |
| publicationDate | 2003-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03095640-A2 |
| titleOfInvention | Transgenic rat as animal model for human huntingdon's disease |
| abstract | Huntingdon's Disease (HD) is an autosomal-dominant inherited progredient neurodegenerative disease from the group of CAG repeat/polyglutamine diseases and is characterized by a triad of psychiatric modifications, dementia and motory function disorders. On a sub-cellular level, a mutation with extended CAG trinucleotide repeats has been identified as the cause of Huntingdon's Disease. The therapeutic effects of certain substances can be tested on the neurochemically indicated transgenic animal models with expanded CAG repeats. In the present invention, transgenic rats were generated and characterized for human HD. Said rat model for human HD and other diseases of the CNS includes 51 CAG repeats under the control of a rat promoter and has a slowly progredient neurological phenotype closely reflecting human HD syndrome. The comparability of the rat model in relation to human HD is characterized by neuropathological, neuroradiological and neurochemical modifications accompanied by typical behavioural abnormalities. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011046189-A1 |
| priorityDate | 2002-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.