| abstract |
In a dispersion of lipids in a dispersing medium, the said lipids comprising an amino-amidine compound A, the amidine function of the said compound A is titrated substantially in water by means of an acid HX, wherein X is an anion, in a manner such that the pH of the said lipid dispersion is between about 6.5 and 7.8 within a temperature range from about 2°C to 40°C. The so titrated dispersion is useful inter alia as a component of a synthetic vector for therapeutic molecules or macromolecules. |