| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcec30486412ec5bcc7d9e283309ae63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5b96e70bcae0a8d841ee24c719caea0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bad5c5accd21da5208a6c44bf42dffff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d48f8c03b846acfb609b826f1a9f3e9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66 |
| filingDate |
2003-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a375c049c6b11e1b9e9d62535b0082
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b37bc9a7f898e8a6c6833bbbf57018b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59173baf3fc8b244d440fe5add03a599 |
| publicationDate |
2003-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-03093498-A1 |
| titleOfInvention |
Inhibition of protein tyrosine phosphatases and sh2 domains by a neutral phosphotyrosine mimetic |
| abstract |
Methods of inhibiting protein tyrosine phosphatases (PTPs) and Src homology 2 domains (SH2) using neutral phosphotyrosine (pY) mimetics (PTP inhibitors) are provided. Neutral pY mimetics, or PTP inhibitors comprising an aldehyde or mono-ketone substituted aryl group are also provided. Substituents on the aryl groups of the PTP inhibitors provide further affinity for particular PTPs. PTP inhibitors comprising a reactive tripeptide substituent are also provided. Methods of using the neutral, reversible inhibitors as probes for studying the physiological functions of PTPs and SH2 domains are also provided. Methods of treating type II diabetes and obesity by administering a neutral pY mimetic that selectively and reversibly binds with PTP1B are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1435989-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1435989-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10206877-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022165606-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010048144-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9732080-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010048144-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7736911-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102186505-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7541485-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7553873-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10081621-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011087823-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10071979-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7998965-B2 |
| priorityDate |
2002-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |