| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_74da163d12e1fc8d3382e9a61798cd65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f73390d83a05db517bcefbf73d9039b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_802c1e3c89189e53e0895f19c4b86f77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00468d7779698afd6ab77df3b0893137 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0004 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
2003-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43180470b00119f338833896d49aebb8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fde54fba68d7ab8ee5c96ec22073d035
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a96bf6fec9543a95b761b9307a4e99a0 |
| publicationDate |
2003-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-03091694-A2 |
| titleOfInvention |
Method for assay of cognition and memory based on low frequency stimulation |
| abstract |
The invention provides an in vitro method for eliciting long term potentiation (LTP) in the neuronal tissue of an animal using an electrical stimulation protocol that ranges from 4 to 12 Hz. The stimulation is applied over a short time course and yields an enhanced electrophysiological output which lasts for several hours. The method can be used to identify compounds, which can be used for enhancing LTP in an animal and ultimately cognitive performance and memory, as well as for developing pharmacological treatments for learning or memory impairments in e.g., aged humans with pathological memory impairments such as Alzheimer's disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8884017-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7725192-B2 |
| priorityDate |
2002-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |