| abstract |
A modified-release vasopeptidase inhibitor formulation is provided which is capable of releasing vasopeptidase inhibitor, preferably omapatrilat or gemopatrilat, in a manner to provide therapeutically effective NEP inhibitory activity and therapeutically effective ACE inhibitory activity, in a balanced manner, for a predetermined duration to lower blood pressure and/or treat heart failure. In a preferred formulation, the NEP inhibitory activity and ACE inhibitory activity have balanced release characteristics. Combinations including the above formulation and a diuretic and/or other therapeutic agents and methods for lowering blood pressure employing the above formulation and/or combination and a method for enhancing or balancing NEP inhibitory activity of a vasopeptidase inhibitor are also provided. |