| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d0b61b4d257b17d228dfcd4215f074e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dca017096dad6a50f19415cee7f4b0cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e119319d41dec89b6a9c19321b8bab39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1323
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-094 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4747
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0698 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2003-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f3f3d34f1390f02aaef6b34b4da3a4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90162a41f1d7e3b2da48ff919bf2f579
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_480d0030d467ad05141b4a745be9bef6 |
| publicationDate |
2003-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-03087337-A2 |
| titleOfInvention |
Vascularized human skin equivalent |
| abstract |
Clinical performance of currently available human skin equivalents is limited by failure to develop perfusion. To address this problem we have developed a method of endothelial cell transplantation that promotes vascularization of human skin equivalents in vivo. Living skin equivalents were constructed by sequentially seeding the apical and basal surfaces of acellular dermis with cultured human keratinocytes and Bcl-2 transduced HUVEC or umbilical cord cells sequentially. After orthotopic implantation of grafts comprising cultured human keratinocytes and Bcl-2 transduced HUVEC cells onto mice, the grafts displayed both a differentiated human epidermis and perfusion through the HUVECÂlined microvessels. These vessels, which showed evidence of progressive maturation, accelerated the rate of graft vascularization. Successful transplantation of such vascularized human skin equivalents should enhance clinical utility, especially in recipients with impaired angiogenesis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2006247228-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2441268-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2441268-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9315778-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006125025-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8518436-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11478574-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8084055-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006125025-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9867905-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9878071-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8512756-B2 |
| priorityDate |
2002-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |