| abstract |
BMAL1, BPL1, KIAA1491 complete (SEQ ID NO:1) and KIAA0596CT (SEQ ID NO:2) having a function of interacting with c-Jun N-terminal kinase 3 are found out. Using them and peptides originating therein, drugs and medicinal compositions to be used in inhibiting the phosphorylation of c-Jun, inhibiting the functions (for example, transcription activation) of c-Jun, inhibiting apoptosis (for example, apoptosis in nerve cells) and preventing and/or treating neurodegenerative diseases (for example, polyglutamine disease and Alzheimer’s disease) and a method therefor are provided. |