| abstract |
A PTX3 gene expression suppressor comprising a compound represented by the following formula (1): OH OH | |R1-X-CH-CH2-CH-CH2-COOR2 (1)wherein R1 represents an organic group, X represents -CH2CH2- or -CH=CH-, and R2 represents a hydrogen atom or an alkyl group, or a lactone derivative thereof, or a salt thereof.According to the present invention, a PTX3 gene expression suppressor useful for the treatment of autoimmune diseases, especially rheumatoid arthritis can be provided. |