| abstract |
A medicinal composition which contains a compound represented by the general formula (I): (I) wherein R1 is hydroxy, etc.; R2 is optionally substituted lower alkyl, etc.; R3 is hydrogen, etc.; R4 is optionally substituted allylene, etc.; R5 is a single bond, -C≡C-, etc.; and R6 is optionally substituted aryl, etc.), an optically active isomer thereof, a prodrug thereof, a pharmaceutically acceptable salt of any of these, or a solvate of any of these. It has decomposition inhibitory activity against the extracellular matrix of a cartilage. |