http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03078599-A3

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filingDate 2003-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-03078599-A3
titleOfInvention Method for generating primate trophoblasts
abstract The first method to cause a culture of human and other primate stem cells to directly and uniformly differentiate into a committed cell lineage is disclosed. Treatment of primate stem cells with a single protein trophoblast induction factor causes the cells to transform into human trophoblast cells, the precursor cells of the placenta. Several protein factors including bone morphogenic protein 4 (BMP4), BMP2, BMP7, and growth and differentiation factor 5 can serve as trophoblast-inducting factors.
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