| abstract |
Polymorphic forms of 9-nitrocamptothecin (9NC) are provided. Distinct crystal forms of 9NC are obtained from crystallization in different solvent systems and under various conditions, and are further charactherized using various analytical methods. For example, a particular crystal form of 9NC is provided which is charactherizable as having, by differential scanning calorimetry, an endotherm at between 175.5 and 177.2C, an exotherm at between 181.7 and 183.7C, and an IR spectrum with no absorption centered between 3625cm-1 and 3675cm-1. |