http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03070266-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3873abaff397acbfffa1595a12cfef41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b23fc96adda0588adeda7356f0250bd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_93e7de1fa22b54995a54749e100c4b7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6115b7f4561db088f26a575e9339fed0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001182 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate | 2002-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81381451b1d5d853bfffa00c1b0df10e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15c420e5348618962eac424f93010b24 |
| publicationDate | 2003-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03070266-A1 |
| titleOfInvention | Enhanced immunization and suppression of oral tolerance |
| abstract | This invention provides for methods of immunizing mammals against tumors expressing a carcinoembryonic antigen using a carcinoembryonic immunogen modified to lack cellular immunosuppressive activity or CD1d binding. The invention further provides for use of a carcinoembryonic immunogen having a region recognized by antibody B9 or L12 modified to inactivate cellular immunosuppressive activity. Methods are also provided for modifying the immunogen by deleting, altering, mutating or truncating the immunosuppressive region. The invention also provides for enhancing cellular immunogenicity of an orally delivered immunogen by co-administration of an agent capable of inhibiting the immunosuppressive activity of carcinoembryonic antigen. Further methods are provided for treating a patient having a carcinoembryonic-antigen-family-member-expressing tumor by immunizing the patient with the carcinoembryonic-antigen-family-member lacking the immunosuppressive region. Pharmaceutical compositions for eliciting an effective immune response to the carcinoembryonic antigen are also provided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009040418-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006040481-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2876798-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501192-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9176131-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006040481-A3 |
| priorityDate | 2001-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.