| abstract |
4’-C-Cyano-2’-deoxypurine nucleosides represented by the following general formula [I] which have an excellent anti-HIV effect, in particular, an efficacy on multidrug-resistant HIV strains having resistance to a plural number of anti-HIV drugs such as AZT, ddI, ddC, d4T and 3TC without causing any problems in cytotoxicity; and medicinal compositions comprising such a compound and a pharmaceutically acceptable carrier: [I] wherein B represents a purine base; and R represents hydrogen or phosphate. |