| abstract |
A pharmaceutical composition useful for sustained/extended release of a therapeutically active ingredient to an environment of use, said composition comprises a tablet core composition consists of a therapeutically active ingredient that is weakly acidic in nature and has a limited solubility in the aqueous environment, said the therapeutically active ingredient is in immediate contact with the agents that are capable of improving the solubility of the agent within the core, for e.g., by changing the micro environmental pH of the core and the tablet core is surrounded by a release rate controlling membrane consisting of a semi-permeable membrane forming polymer, permeable membrane forming polymer, and at least one plasticizer capable of modulating the film formation properties of the polymers. |