abstract |
Quinazoline or quinoline derivatives of formula: (Formula I and II); wherein Z is CH or N; Y is O or S; X is OR5 or NR5R6; R1, R2, R3, R4, R5 and R6 are as disclosed. Also described is a method for the inhibiting the prolyl peptidase, inducing apoptosis and treating cancer by administering a therapeutically effective amount of compounds of the formula (I) or (II). |