abstract |
Compounds having the formula (I), wherein R3 is selected from H, OH and NH2; R30 is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O)¿2?-; or W may be -CH2- if X is -C(=O)-; X is selected from -CH2-, -N(R?4¿)-, and -O-, except that when W is -CH¿2?-, X is -C(=O)-; Y is a bond or -C(R?40)(R45¿)-; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and X?1, X2, X3, X4, X5, X6, X7, X8, X9, X10 and X11¿ are selected such a tricyclic heteroaryl ring system is formed as further defined in the specification. |