| abstract |
The invention provides adenoviral vectors possessing fibers that do not bind CAR, a receptor-targeting ligand sequence, the non-receptor targeting sequence derived from HIV-TAT, a sequence encoding the HI loop of the non-CAR binding adenovirus fiber, which permits specific receptor-targeted transduction with the recombinant adenovirus vectors. The invention also provides related chimeric proteins, adenovirus particles and mammalian cells. |