http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03045962-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67985a26a159d011cdb7a89a9c993928 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eba0008db494072f01570263a1cb6263 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_465c823863e88873746cafc7eb9d8b3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a0cade92f51cbc620252e8e7b9de95e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0093 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C61-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-255 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 |
| filingDate | 2001-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9283d19001a3d4a167e086e5af3e3a2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0ae356d59d35ea3ee5fe0363582225e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e362619243fdfa0d7f8457eed344c9a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48140f5384083fbe80cc2f1f4b1a9a4e |
| publicationDate | 2003-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03045962-A1 |
| titleOfInvention | Supermolecular carboplatinum derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions |
| abstract | The present invention relates to a novol class of supermolecules carboplatinum derivatives represented by general formula (I), wherein B is a polycarboxylic represented by general formula (II), wherein (R1) and (R2) and (n) is defined as in the description. This invention also relates to method of preparing the same, relates to pharmaceutical composition containing the same as active principle and the use of the derivatives in the preparation of pharmaceutical compositions which are useful in treating several cellular cancers including hepatoma, stomach cancer, lung cancer, etc. The derivatives have stable cage-like chemical structures and constituitions in solid and in aqeous solution. The derivatives can not only induce the fatality of several cancer cells at a rate significantly higher than that by carboplatinum, in particular, on hapatoma cells, at a rate one to two times higher than that by carboplatinum, but also produce little side effects such as vomit, baldness, decreases of leucocytes and platelets, which can be resulted by administration of other chemotherapeutics. The acute doxity dose LD50 of the present derivatives is about 300mg/kg and 260mg/kg weight body for a subcutaneous and a intraperitoneal administration respectively. Therefore, the novol class of cis-platium of the present derivatives have a wide prospective of application as anticancer agents. |
| priorityDate | 2001-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.