| abstract |
Using the expression of a molecular chaperone GRP78 as an indication, attempts have been made to search for a substance capable of controlling the expression of GRP78. As a result, versipelostatin (also called JL68) represented by the formula (I), which is a novel tetronic acid derivative having an activity of inhibiting the GRP78 expression, is isolated from a metabolite of Streptomyces versipellis 4083-SVS6 strain. This versipelostatin can be obtained by culturing the Streptomyces versipellis 4083-SVS6 strain and collecting from the culture supernatant. |