| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fe0d6fbba99168ba3ccf6f64c72cdb7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dddcfe22dc57d2996ec580fa8f409db3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fc6c2e9e63b6561f2f46b1de31f6379
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dab60f84941491eaeb05127b575754b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d67540d0f3ea8514d81c36009651b69a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate |
2002-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ca3090b73d335fcdea37e266547404e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee389aefa81cd46fcaba17427e872852
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_406c75a0e68d1ba8bf84b3354b34cec5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_802edb295cf5d2b142d50a53ce074db1 |
| publicationDate |
2003-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-03041128-A2 |
| titleOfInvention |
Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| abstract |
A method for enhancing cellular uptake and redistributing gene regulating polyamides from the extranuclear areas in eukaryotic cells to the nucleus thereof. The method consists of administering to the eukaryotic cells a molecular trafficking compound. The administered molecular trafficking compound affects cellular pathways and mechanisms that accumulate polyamides in cytoplasmic vessicles and/or efflux polyamides from the intracellular regions of cell. The method also includes modifying polyamides to contain negatively-charged or acidic moieties wherein the moieties inhibit the accumulation of polyamides in cellular lysosomes. By affecting the cellular pathways and mechanisms, the polyamides are redistributed throughout the cell, whereby nuclear accumulation of the polyamides is enhanced. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9630950-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307401-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8835480-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005033077-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8017599-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009128547-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935530-B2 |
| priorityDate |
2001-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |