http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03038032-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c9a912a719976bd93bc6762b5417c381 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-13 |
| filingDate | 2002-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62bd14599f760b90026b85e158b49078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b11553fcfd9e79f274f2141da11c335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cc75094df3f0402c01fe7ed5375c912 |
| publicationDate | 2003-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03038032-A2 |
| titleOfInvention | Means for inhibition of the synthesis of viral proteins |
| abstract | The invention relates to means for inhibition of primate lentiviruses, in particular the use of PPIase inhibitors as means for inhibiting human immune deficiency viruses type 1 and 2 (HIV-1 and HIV-2) and simian immune deficiency viruses (SIV). It can be shown using viral protein R (Vpr), that inhibitors of cellular peptidyl-prolyl cis/trans isomerases (PPIases) inhibit the expression, folding protein stability and the biological efficacy of Vpr. The anti-viral effect of PPIase inhibitors, in particular, cyclosporin A, is based on a specific interaction of PPIases, in particular of cyclophilin A, with prolines on the N-terminus of Vpr. Applications are in anti-retroviral therapy and prevention of infections with lentiviruses which cause immune deficiency in humans and animals, in particular of AIDS or HIV-induced pathological conditions, also in combination with other anti-retroviral medicaments. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005063281-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005063281-A3 |
| priorityDate | 2001-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.