| abstract |
Heterocyclic compounds represented by the general formula (|) or salts thereof, having excellent inhibitory activity against tyrosine kinase; and pharmaceutical compositions containing the same: (|) wherein m is an integer of 1 to 3; n is 1 or 2; R1 is halogeno or optionally halogenated C1-2 alkyl; R2 and R3 are each hydrogen, halogeno, lower alkyl, or lower alkoxy; and R4 is a group represented by the general formula (IIa) or (IIb): (IIa) (IIb) (wherein p is an integer of 2 to 5; and R5 is C1-4 alkyl substituted with alkoxycarbonyl, carbamoyl, carbamoyloxy, alkylsulfonyl, alkylsulfinyl, sulfamoyl, carbamoylamino, alkylsulfonylamino, acylamino, or the like). |