http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03029400-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5e95156255d5fe8b2923c544786e176 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
| filingDate | 2002-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11d9190dbb6607f266b926df517717ac |
| publicationDate | 2003-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03029400-A2 |
| titleOfInvention | Cell lines for productive infection of hepatitis b virus |
| abstract | The present invention provides a hepatoma cell that is capable of supporting infection by HBV. The hepatoma cell is modified to have at least one endogenous SPI gene modified so as not to express any functional SPI protein. In another embodiment the heptaoma cell is modified so as to express an antisense oligonucleotide that hybridizes to the SPI RNA, thereby inhibiting the expression of the SPI protein. Both modifications allow for the injection of HBV, therein providing a long sought, yet unfulfilled need for a liver cell line to study the mechanisms of hepadnaviral infectivity as well as to test for novel anti-HBV therapeutics. |
| priorityDate | 2001-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 419.