| abstract |
Novel benzene derivatives represented by the general formula (|), which exhibit vanilloid receptor agonism and are useful as preventive and therapeutic drugs for pollakisuria and urinary incontinence, analgesic, or the like: (|) wherein R1, R4 and R6 are each independently hydrogen, halogeno, or hydrocarbyl; R2 is hydrocarbyl or a heterocyclic group; R3 is hydrocarbyl, NR7’R7, or OR8 (wherein R7’ is hydrogen or hydrocarbyl and R7 is a non-aromatic group, or alternatively R7’ and R7 together with the nitrogen atom adjacent thereto may form a ring; and R8 is hydrocarbyl or a heterocyclic group); R5 is hydrocarbyl or a heterocyclic group (except quinolyl) and R5’ is hydrogen or hydrocarbyl, or R5 and R5’ together with the nitrogen atom adjacent thereto may form a ring; and R5’’ is hydrogen or hydrocarbyl. |