| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78587acbfc8d4c9e9ac3baa7021087d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f5d1ac47a0b7cf0981654becfe992d9b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-168
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-51 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L1-305
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-00 |
| filingDate |
2002-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b920cf8cd7438d64f7bb1fcf03afb91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39cda146147b8e5c4040d194eb2f35a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0a2c7b83648c854381b95870536fbad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f96a812fbdb1fca10812ef3bd9b882e |
| publicationDate |
2003-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-03020305-A1 |
| titleOfInvention |
Methionine restriction for cancer therapy |
| abstract |
The present invention is directed to methods and compositions regarding induction of apoptosis in a cell and treatment of cancer in an individual wherein methionine deprivation of the cell is followed by methionine repletion of the cell. The methionine deprivation of the cell results in G2 arrest in the cell, leading to DNA damage in the cell. Upon readministration of methionine to the cell, the damaged cell exits G2 arrest and enters into apoptosis. In a specific embodiment, a therapeutic effect is elicited by cycling the patient between a methionine-depleted diet and a normal, methionine-replete diet. The present invention also regards chronic methionine deprivation for treatment of cancer in a human, in addition to methods for methionine restriction as adjunctive therapy for other cancer treatment methods. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3583956-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018241657-B2 |
| priorityDate |
2001-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |