abstract |
Short double stranded RNA (dsRNA) oligonucleotides homologous to regions of hepatitis C virus target RNA polynucleotide sequences are provided. Also provided are methods of attenuating the expression of hepatitis C virus genes, attenuating the function of hepatitis C virus target RNA polynucleotide sequences required for virus infection, replication, or pathogenesis, and otherwise inhibiting hepatitis C virus infection, replication, and/or pathogenesis by administering one or more of these short dsRNAs to prevent or treat hepatitis C virus infections in humans. |